Altered interactions between lipogenesis and fatty acid oxidation in regenerating rat liver
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چکیده
منابع مشابه
Altered interactions between lipogenesis and fatty acid oxidation in regenerating rat liver.
The concentrations of malonyl-CoA, citrate, ketone bodies and long-chain acylcarnitine were measured in freeze-clamped liver samples from fed or starved normal, partially hepatectomized or sham-operated rats. These parameters were used in conjunction with measurements of the concentration of plasma non-esterified fatty acids and the rates of hepatic lipogenesis to obtain correlations between ra...
متن کاملFlexibility of zonation of fatty acid oxidation in rat liver.
Periportal and perivenous hepatocytes were isolated from rats subjected to different treatments that induce (starvation, cold exposure) or depress (refeeding after starvation) hepatic fatty acid oxidation. These experiments were designed to determine factors that may be involved in creating and maintaining the asymmetrical distribution of this metabolic pathway in the acinus of the liver. The u...
متن کاملHepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.
Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de novo lipogenesis (DNL) and protects against diet-induced hepatic steatosis and adiposity. To understand the mechanism by which hepatic MUFA production influences adipose t...
متن کاملBritain Fatty Acid Synthesis in the Regenerating Liver of the Rat
1. Synthesis de novo of fatty acids in the rat liver, measured per g wet wt. of tissue, was increased by a factor of about two, between 1 and 4 days after partial hepatectomy, compared with rates in sham-operated control rat livers. 2. There were no associated changes in the rates ofliver cholesterol synthesis or of adipose-tissue fatty acid synthesis in rats after partial hepatectomy, compared...
متن کاملControl mechanisms of gluconeogenesis and ketogenesis. II. Interactions between fatty acid oxidation and the citric acid cycle in perfused rat liver.
Previous work has shown that gluconeogenesis from a variety of substrates is stimulated by oleate. This paper reports data on the effect of oleate on tissue levels of coenzyme A derivatives, ketone bodies, citric acid cycle intermediates, and adenine nucleotides in rat livers perfused with alanine, lactate, or pyruvate. The effect of oleate on the activity of the citric acid cycle with lactate ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1987
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2410469